Hybrid lubricants combine the slickness of silicone-based lube and the smoothness of water-based lube. Perfect when you'd like the best of both worlds Compared to water-based lubes, hybrids are smoother and creamier and longer-lasting. Most importantly, hybrid lubes are safe for anal, vaginal, and oral sex. Many hybrid lubes are also stain resistant so they won’t ruin your sheets or your clothes.